ANTIBODY GENERATION



NON-IMMUNOGENIC BECOMES IMMUNOGENIC

The EAP™ (Enhanced Affinity Platform) System is a conceptually unique immunization scheme, modeled on the rapid and powerful immune response to viral antigens. Unlike the antibody responses used in traditional approaches, antiviral responses happen in days, not weeks, and give rise to high-affinity antibodies targeting a broad range of epitopes, not just a few immunodominant ones. The EAP™ System achieves this by pre-conditioning the host immune system for a potent response to specifically modified antigen. In addition to the speed and broad range of the antibody response, a major benefit of the EAP™ is its ability to induce high-specificity antibodies to minute determinants, including single-atom differences.

A key advantage of the EAP™ System is the simple and easy production of immunogens and screening materials – whether the target is a protein, peptide, or small molecule. The EAP™ immunogens and screening materials are designed to generate and identify MAbs tailored to the most specific acceptance criteria for IHC, flow cytometry, function blocking/activation, diagnostic applications, and lateral flow test kits.







A HISTORY OF SUCCESS

In 20+ years of continuing optimization, the EAP™ System has successfully produced >1,300 MAbs for previously unaddressable targets. EAP™-derived MAbs at are the core of SLRC’s Watersafe® Lead and Pesticide Tests; the RapidBac™Vet Bacteria Test; and the HemoTypeSC™ Test for sickle-cell disease. Many EAP™ MAbs are available through SLRC’s reagent catalog.




PATENTED ASSAYS AND TEST KIT FORMATS



SLRC’s immunoassay formats have been developed to take full advantage of the diagnostic potential of EAP™-derived antibodies. Our lateral flow tests (LFAs) are rapid, one-step, low cost solutions to a variety of diagnostic problems, bringing laboratoryaccuracy to on-site and POU/POC testing. SLRC’s formats are protected by a series of issued and pending patents.

Sandwich-PLUS: Novel assays for proteins, microbiological tests, and other large analytes

Sandwich-PLUS™ is a patent-pending format that improves antibody-antigen binding kinetics and virtually eliminates cross-reactivity and sensitivity problems that result from inefficient binding of surface-attached antibodies.

IR (internally referenced) competitive assays for small molecules

Competitive immunoassays are the preferred method for detection of small molecules (<2000 daltons molecular mass), including drugs, environmental contaminants, and small peptides. SLRC’s patented IR-competitive™ formats offer A p
re-set internal reference for semi-quantitative results and extreme sensitivity to < 1 ppb (ng/ml). The IR-competitive™ formats are used in our Watersafe® products, including the Watersafe® Lead Test - the world's first and only rapid immunoassay detecting picomolar quantities of single atoms (Pb++).



PARTNERSHIPS



We develop custom MAbs and diagnostics in partnership with:
  • Diagnostics and Biopharmaceutical Companies
  • Consumer Product Companies
  • Academia
  • Government agencies

Partnering Opportunities:
info@silverlakeresearch.com



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